ABSTRACT
Objective: To investigate the difference of ovarian benign diseases and healthy regulatory T cells (Tregs) and tumor markers CA 125 and CA 19-9 in patients with ovarian cancer, and to analyze their correlation with clinicopathological factors and prognosis. Methods: We selected 43 cases pathologically diagnosed ovarian cancer patients in gynecological department from October 2016 to October 2017 in our hospital as a malignant group, another 55 cases of benign ovarian patients treated in the same period as benign group, 50 cases of healthy physical examination women as control group. The Tregs number and expression levels of tumor markers CA 125 and CA 19-9 in ovarian cancer were compared among the three groups, and their relationship with clinicopathological factors and prognosis was analyzed. Results: The proportions of Tregs in the malignant and benign groups were higher than those in the control group, and the proportions of Tregs, CA 125 and CA 19-9 in the malignant group were higher than that in the benign group (P0.05). Conclusion: Tregs, CA 125, and CA 19-9 can all be promising markers for clinical diagnosis, treatment and prognosis of ovarian cancer.